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cannabidiol (CBD) ist ein nichtpsychoaktives Cannabinoid aus dem weiblichen Hanf Cannabis sativa. Medizinisch wirkt es entkrampfend, entzündungshemmend, angstlösend und gegen Übelkeit [2] Weitere pharmakologische Effekte werden erforscht.

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Beim Konsum von Hanfprodukten (Haschisch, Marihuana) als Freizeitdroge bewirkt ein hoher CBD-Anteil eine eher sedierende, ein niedriger CBD-Anteil eine eher anregende Wirkung. Indischer Hanf (Cannabis Indica) enthält meist mehr CBD als Nutzhanf (Cannabis Sativa). Perish Konzentrationen von THC (Tetrahydrocannabinol) und CBD verhalten sich antiproportional zueinander.

CBD geht unter Einwirkung von Säuren in Δ8- und Δ9-THC über [3] In harsh basischem Milieu findet durch Luftsauerstoff eine Oxidation zu einem Chinon statt [4] Bei längerer Lagerung in Gegenwart von Luft wird es zu Cannabinol dehydriert.

CBD bindet nicht pass away bekannten Cannabinoid-Rezeptoren CB1 und CB2, jedoch blockiert es deren Aktivität über einen ungeklärten Mechanismus [5] Es wirkt jedoch als Antagonist an dem G-Protein gekoppeltem Rezeptor GPR55, dessen physiologische Rolle noch nicht geklärt ist [6]

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Non-psychotropic component of marijuana that is actually anticonvulsive, antihyperalgesic and also neuroprotective in vivo. GPR55 as well as feeble CB1 villain (IC50 market values are actually 0.445 and also 3.35 μμ M), CB2 receptor inverted agonist as well as prevention of anandamide uptake (IC50 = 27.5 μ& mu; M). Additionally a weaker agonist at VR1 vanilloid receptors (EC50 = 3.5 μ& mu; M).

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(2004) Vanilloid TRPV1 receptor resolves the antihyperalgesic result of the nonpsychoactive cannabinoid, cannabidiol, in a rodent design of intense inflammation.Br.J.Pharmacol.143.
( 1998) Complex pharmacology of all-natural cannabinoids: documentation for predisposed agonist action of ΔΔ 9-tetrahydrocannabinol and also villain action of cannabidiol on rodent human brain cannabinoid receptors.Life Sci.63.
( 2007) The stray receptor GPR55 is actually an unfamiliar cannabinoid receptor.Br.J.Pharmacol.152.
( 2007) Cannabidiol presents all of a sudden higher effectiveness as a villain of CB1 and also CB2 receptor agonists in vitro.Br.J.Pharmacol.150.
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Keywords: (-)- cannabidiol , (-)- cannabidiol vendor, Natural, cannabinoids, AMT, preventions, hinders, GPR55, villains, unstable, CB1, CB2, inverted, agonists, Anandamide, Transporters, Monoamine, Neurotransmitter, Non-Selective, Receptors, cb2r, cb1r, CBD, Cannabinoid, Non-selective, Cannabinoids, 1570, Tocris Bioscience

Citations are actually magazines that utilize Tocris items. Chosen citations for (-)- cannabidiol consist of:

(2011) cannabidiol minimizes Aβ-induced neuroinflammation as well as advertises hippocampal neurogenesis with PPARγ participation. Proc Natl Acad Sci U S A6

(2018) cannabidiol boosts MOR antinociception, decreases NMDA-mediated convulsions as well as lowers shock damages by means of the sigma 1 receptor. Mol Brain11

(2011) Increasing antiproliferative buildings of endocannabinoids in N1E-115 neuroblastoma tissues by means of restraint of their metabolic process. PLoS One6

(2009) The suppositious cannabinoid receptor GPR55 impacts osteoclast feature artificial insemination as well as bone tissue mass in vivo. PLoS One106

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A compilation of over 450 items for G protein-coupled receptors, the list features investigation resources for the research study of:

An assortment of over 275 items for neurodegeneration study, the overview consists of research study devices for the research of:

An assortment of over 250 items for ache analysis, the manual features research study devices for the research study of:

Written through Roger Pertwee, this testimonial talks about substances which impact the task of the endocannabinoid device, concentrating specifically on ligands that are actually very most largely made use of as speculative resources as well as signifies materials on call coming from Tocris.

Highlights over 450 items for GPCRs.

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Our Cannabinoid evaluation provides a review of the medicinal ligands made use of to analyze the cannabinoid CB1 and also CB2 receptors.

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